Standing on the Shoulders of Giants: Challenges and Recommendations of Literature Search in Information Systems Research

The “standing on the shoulders of giants” metaphor is often used to acknowledge the work of others when undertaking research and, in particular, stresses the importance of literature reviews in scientific inquiry. Though the significance of literature reviews has never been in doubt, researchers, especially novice researchers, still struggle with developing effective strategies for reviewing literature. An important reason for this difficulty is the rapidly increasing number of potentially relevant publications—not all of which necessarily add value to a literature review. As such, avoiding standing on the shoulders of dwarfs literature search emerges as a major issue in crafting an effective literature review. In this paper, we discuss challenges of literature searches in the increasingly dynamic context of information systems (IS) research and make recommendations for how to deal with them. We present practical guidelines and a checklist to help researchers with planning and organizing their literature searches

Projektübergreifendes Management - Der strategische Applikationslebenszyklus am Beispiel des BMW Q-Cockpit

Zusammenfassung: Oft scheitern oder verzögern sich Softwareprojekte, weil die Veränderungsfähigkeit des Unternehmens überschätzt wird und zu viele Zielsetzungen gleichzeitig verfolgt werden. Basierend auf den Erkenntnissen aus einem Entwicklungsprojekt bei der BMW Group werden die Ziele für eine nachhaltige Softwareentwicklung und -einführung anhand eines strategischen Applikations-Lebenszyklus (SALZ) auf vier Evolutionsphasen verteilt. Diese verzahnte Entwicklung von Software und Geschäftsprozessen ist der Schlüssel für ein nachhaltiges und erfolgreiches Business-IT-Alignment (BITA) auf der Applikationsebene

Genetic Stability of Driver Alterations in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type and Their Relapses:A Rationale for the Use of Molecular-Based Methods for More Effective Disease Monitoring

Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is a rare, aggressive cutaneous lymphoma with a 5-year disease-specific survival of only ~55%. Despite high response rates to initial immune-polychemotherapy, most patients experience a disease relapse. The genetic evolution of primary and relapsed/refractory disease has only scarcely been studied in PCDLBCL-LT patients. Therefore, in this retrospective cohort study, 73 primary/pre-treatment and relapsed/refractory biopsies of 57 patients with PCDLBCL-LT were molecularly characterized with triple FISH and targeted next-generation sequencing for 52 B-cell-lymphoma-relevant genes, including paired analysis in 16 patients. In this cohort, 95% of patients harboured at least one of the three main driver alterations (mutations in MYD88/CD79B and/or CDKN2A-loss). In relapsed/refractory PCDLBCL-LT, these oncogenic aberrations were persistently present, demonstrating genetic stability over time. Novel alterations in relapsed disease affected mostly CDKN2A, MYC, and PIM1. Regarding survival, only MYC rearrangements and HIST1H1E mutations were statistically significantly associated with an inferior outcome. The stable presence of one or more of the three main driver alterations (mutated MYD88/CD79B and/or CDKN2A-loss) is promising for targeted therapies addressing these alterations and serves as a rationale for molecular-based disease monitoring, improving response evaluation and early identification and intervention of disease relapses in these poor-prognostic PCDLBCL-LT patients

MYD88 mutations identify a molecular subgroup of diffuse large B-cell lymphoma with an unfavorable prognosis

The 2016 World Health Organization classification defines diffuse large B-cell lymphoma (DLBCL) subtypes based on Epstein-Barr virus (EBV) infection and oncogenic rearrangements of MYC/BCL2/BCL6 as drivers of lymphomagenesis. A subset of DLBCL, however, is characterized by activating mutations in MYD88/CD79B. We investigated whether MYD88/CD79B mutations could improve the classification and prognostication of DLBCL. In 250 primary DLBCL, MYD88/CD79B mutations were identified by allele-specific polymerase chain reaction or next-generationsequencing, MYC/BCL2/BCL6 rearrangements were analyzed by fluorescence in situ hybridization, and EBV was studied by EBV-encoded RNA in situ hybridization. Associations of molecular features with clinicopathologic characteristics, outcome, and prognosis according to the International Prognostic Index (IPI) were investigated. MYD88 and CD79B mutations were identified in 29.6% and 12.3%, MYC, BCL2, and BCL6 rearrangements in 10.6%, 13.6%, and 20.3%, and EBV in 11.7% of DLBCL, respectively. Prominent mutual exclusivity between EBV positivity, rearrangements, and MYD88/CD79B mutations established the value of molecular markers for the recognition of biologically distinct DLBCL subtypes. MYD88-mutated DLBCL had a significantly inferior 5-year overall survival than wild-type MYD88 DLBCL (log-rank; P=0.019). DLBCL without any of the studied aberrations had superior overall survival compared to cases carrying .1 aberrancy (log-rank; P=0.010). MYD88 mutations retained their adverse prognostic impact upon adjustment for other genetic and clinical variables by multivariable analysis and improved the prognostic performance of the IPI. This study demonstrates the clinical utility of defining MYD88-mutated DLBCL as a distinct molecular subtype with adverse prognosis. Our data call for sequence analysis of MYD88 in routine diagnostics of DLBCL to optimize classification and prognostication, and to guide the development of improved treatment strategies

No preclinical rationale for IGF1R directed therapy in chondrosarcoma of bone

Background: Chondrosarcoma is a malignant cartilage forming bone tumour for which no effective systemic treatment is available. Previous studies illustrate the need for a better understanding of the role of the IGF pathway in chondrosarcoma to determine if it can be a target for therapy, which was therefore explored in this study. Methods: Expression of mediators of IGF1R signalling and phosphorylation status of IRS1 was determined in chondrosarcoma cell lines by qRT-PCR and western blot. The effect of activation and inhibition of IGF1R signalling on downstream targets was assessed by western blot. Ten chondrosarcoma cell lines were treated with OSI-906 (IGF1R and IR dual inhibitor) after which cell proliferation and migration were determined by a viability assay and the xCELLigence system, respectively. In addition, four chondrosarcoma cell lines were treated with a combination of doxorubicin and OSI-906. By immunohistochemistry, IGF1R expression levels were determined in tissue microarrays of 187 cartilage tumours and ten paraffin embedded cell lines. Results: Mediators of IGF1R signalling are heterogeneously expressed and phosphorylated IRS1 was detected in 67 % of the tested chondrosarcoma cell lines, suggesting that IGF1R signalling is active in a subset of chondrosarcoma cell lines. In the cell lines with phosphorylated IRS1, inhibition of IGF1R signalling decreased phosphorylated Akt levels and increased IGF1R expression, but it did not influence MAPK or S6 activity. In line with these findings, treatment with IGF1R/IR inhibitors did not impact proliferation or migration in any of the chondrosarcoma cell lines, even upon stimulation with IGF1. Although synergistic effects of IGF1R/IR inhibition with doxorubicin are described for other cancers, our results demonstrate that this was not the case for chondrosarcoma. In addition, we found minimal IGF1R expression in primary tumours in contrast to the high expression detected in chondrosarcoma cell lines, even if both were derived from the same tumour, suggesting that in vitro culturing upregulates IGF1R expression. Conclusions: The results from this study indicate that the IGF pathway is not essential for chondrosarcoma growth, migration or chemoresistance. Furthermore, IGF1R is only minimally expressed in chondrosarcoma primary tumours. Therefore, the IGF pathway is not expected to be an effective therapeutic target for chondrosarcoma of bone. Electronic supplementary material The online version of this article (doi:10.1186/s12885-016-2522-8) contains supplementary material, which is available to authorized users

EXPLORING PATTERNS OF BUSINESS-IT ALIGNMENT FOR THE PURPOSE OF PROCESS PERFORMANCE MEASUREMENT

Having successfully implemented the first phases of their Business Process Management (BPM) initiatives a number of organisations are just now facing the next big challenge: Maintaining the just gained flexibility through continuously measuring and improving their processes’ performance. Although numerous approaches are available there is evidence that companies face severe difficulties in aligning their process-related measurement needs with the appropriate information technology (IT). This study presents and analyses the results of an extracting multiple case study. A framework of four patterns derived in the course of the analysis gives new insights in ways to design business-IT alignment in the context of process performance measurement

EXPLORING THE SHADOWS: IT GOVERNANCE APPROACHES TO USER-DRIVEN INNOVATION

Information Systems (IS) researchers traditionally have the assumption that Information Technology (IT) innovations are conceived within the IT department. Developments like ubiquitous computing, web services and the emerging culture of digital natives challenge this foundational assumption as they enable individuals to implement their own IT innovations quickly. Placing such empowered individuals into a strictly regulated IT environment will drive them away from the IT department and towards their own IT solutions and inevitably to non-compliance. Such user- or business-driven solutions are not necessarily the result of strict policies or limited user rights but may be caused by the inability of the IT department to fulfil business needs. The phenomenon of user-driven fulfilment of requirements is called Shadow IT (SIT). While receiving very limited scholarly attention, SIT is a widespread challenge amongst IT departments. We employ a triangulation approach using three independent data sources to address this phenomenon within the three domains of IS research, IS Security (ISsec), IT Governance (ITG) and Business IT Alignment (BITA). Our findings suggest that practitioners follow three different ITG approaches to SIT based on their business or IT strategy: IT-control, user-oriented and user-driven

RECONSTRUCTING THE GIANT: ON THE IMPORTANCE OF RIGOUR IN DOCUMENTING NTHE LITERATURE SEARCH PROCESS

Science is a cumulative endeavour as new knowledge is often created in the process of interpreting and combining existing knowledge. This is why literature reviews have long played a decisive role in scholarship. The quality of literature reviews is particularly determined by the literature search process. As Sir Isaac Newton eminently put it: “If I can see further, it is because I am standing on the shoulders of giants.” Drawing on this metaphor, the goal of writing a literature review is to reconstruct the giant of accumulated knowledge in a specific domain. And in doing so, a literature search represents the fundamental first step that makes up the giant’s skeleton and largely determines its reconstruction in the subsequent literature analysis. In this paper, we argue that the process of searching the literature must be comprehensibly described. Only then can readers assess the exhaustiveness of the review and other scholars in the field can more confidently (re)use the results in their own research. We set out to explore the methodological rigour of literature review articles published in ten major information systems (IS) journals and show that many of these reviews do not thoroughly document the process of literature search. The results drawn from our analysis lead us to call for more rigour in documenting the literature search process and to present guidelines for crafting a literature review and search in the IS domain

RECONSTRUCTING THE GIANT: ON THE IMPORTANCE OF RIGOUR IN DOCUMENTING THE LITERATURE SEARCH PROCESS

Science is a cumulative endeavour as new knowledge is often created in the process of interpreting and combining existing knowledge. This is why literature reviews have long played a decisive role in scholarship. The quality of literature reviews is particularly determined by the literature search process. As Sir Isaac Newton eminently put it: “If I can see further, it is because I am standing on the shoulders of giants.” Drawing on this metaphor, the goal of writing a literature review is to reconstruct the giant of accumulated knowledge in a specific domain. And in doing so, a literature search represents the fundamental first step that makes up the giant’s skeleton and largely determines its reconstruction in the subsequent literature analysis. In this paper, we argue that the process of searching the literature must be comprehensibly described. Only then can readers assess the exhaustiveness of the review and other scholars in the field can more confidently (re)use the results in their own research. We set out to explore the methodological rigour of literature review articles published in ten major information systems (IS) journals and show that many of these reviews do not thoroughly document the process of literature search. The results drawn from our analysis lead us to call for more rigour in documenting the literature search process and to present guidelines for crafting a literature review and search in the IS domain